Moral courage is the ability to overcome fear and performing the right action based on moral beliefs despite the potential danger. Nurses, as moral agents, need moral courage to properly manage moral problems and make a professional commitment to patients. Therefore, the above study was conducted to investigate the moral courage of nurses and related factors. In this descriptive cross-sectional study conducted in 2019, the research population was all nurses working in Baqiyatallah Hospital. After explaining the objectives of the study and obtaining the consent of the research, 220 nurses were selected as available samples. The data collection tool was Sadooghiasl questionnaire. After completing the questionnaire, they completed 187 sample questionnaires. SPSS software was used to analyze the data. The results of the study showed that the mean score of nurses' moral courage was 413.37 with a standard deviation of 46.70. Thirty percent had moderate moral courage and 69.5% had high moral courage. The results of the independent T-test and ANOVA showed that there is a statistically significant relationship between the variable employment status and the moral courage of nurses. Considering the results of this study and the many ethical challenges that exist in the nursing profession, the issue of moral courage and related factors and providing solutions to improve it, should be at the forefront of the health organization and nursing managers.