Writing treatise on Islah al-Adwiat (Reducing the Side-Effects of Drugs) is one of the most important issues in Islamic medicine. During the first few centuries of Islamic civilization, four important treatises were written on this subject, which established the scientific tradition that formed the bases of the subsequent pharmacological formation. This paper addresses the tradition of writing books on reducing the side-effects of purgatives and it also critically edits and translates the books written by three prominent scholars – Hubaysh b. Atham of Damascus, Qusta b. Luqa of Balbak and Muhammad Zakaria Razi – relying on the surviving manuscripts. The research objective followed by this paper is examining and analyzing the purgatives as an important class in the pharmacological and medical books of the Islamic era.
Almost all books on medicine and pharmacology written in the old medical tradition have a section or a chapter devoted to the detailed introduction of purgatives and counteracting their side effects. Examining these bits, one may trace the main structure of the tradition, which continued for many centuries. Besides, comparing them may provide an appropriate perspective to look at the history of pharmacology. To this end, images of the material included in those books were obtained from libraries and museums, which have housed such books for almost a millennium. Then they were analyzed along with translating and editing.
It may be concluded that pharmacologists belonging to the old medical paradigm would use drugs to treat conditions of bad health caused by changes in the patient’s humors; the drugs, however, would cause some side-effects along with removing humors and residues, leading to a change in the main humor of the body. The pharmacologists; therefore, introduced the drugs, their harms, as well as the best type of the drug to be used and finally suggested some methods in detail to reduce their side effects